Carbon nanotubes in macrophages: Imaging and chemical analysis by X-ray fluorescence microscopy

Nano Letters, 2008, 8(9), 2659-2663

Carbon nanotubes in macrophages: Imaging and chemical analysis by X-ray fluorescence microscopy

Cyrill Bussy, Julien Cambedouzou, Sophie Lanone, Emilie Leccia, Vasile Heresanu, Mathieu Pinault, Martine Mayne-l’Hermite, Nathalie Brun, Claudie Mory, Marine Cotte, Jean Doucet, Jorge Boczkowski and Pascale Launois

X-ray fluorescence microscopy (μXRF) is applied for the first time to study macrophages exposed to unpurified and purified single-walled (SW) and multiwalled (MW) carbon nanotubes (CNT). Investigating chemical elemental distributions allows one to (i) image nanotube localization within a cell and (ii) detect chemical modification of the cell after CNT internalization. An excess of calcium is detected for cells exposed to unpurified SWCNT and MWCNT and related toxicological assays are discussed.

RECENT PUBLICATIONSVIEW ALL

Nature Reviews Materials, 2024, in press

In vivo biomolecule corona and the transformation of a foe into an ally for nanomedicine

Marilena Hadjidemetriou, Morteza Mahmoudi*, Kostas Kostarelos*

FULL ABSTRACT

Nature Nanotechnology, 2024, in press [https://doi.org/10.1038/s41565-023-01572-3]

First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses

Jack Andrews^, Shruti Joshi^, Evangelos Tzolos, Maaz Syed, Hayley Cuthbert, Livia Crica, Neus Lozano, Emmanuel Okwelogu, Jennifer Raftis, Lorraine Bruce, Craig Poland, Rodger Duffin, Paul Fokkens, John Boere, Daan Leseman, Ian Megson, Phil D. Whitfield, Kerstin Ziegler, Seshu Tammireddy, Marilena Hadjidemetriou, Cyrill Bussy, Flemming Cassee, David Newby, Kostas Kostarelos*, Mark Miller*

FULL ABSTRACT

ACS Nano, 2024, published online

Environmental and health impacts of graphene and other two-dimensional materials: a Graphene Flagship perspective

Hazel Lin, Tina Buerki-Thurnherr, Jasreen Kaur, Peter Wick, Marco Pelin, Aurelia Tubaro, Fabio Candotto Carniel, Mauro Tretiach, Emanuel Flahaut, Daniel Iglesias, Ester Vázquez, Giada Cellot, Laura Ballerini, Valentina Castagnola, Fabio Benfenati, Andrea Armirotti, Antoine Sallustrau, Mathilde Keck, Frédéric Taran, Cyrill Bussy, Sandra Vranic, Kostas Kostarelos, Mona Connolly, José Maria Navas, Florence Mouchet, Laury Gauthier, James Baker, Blanca Suarez-Merino, Tomi Kanerva, Maurizio Prato, Bengt Fadeel*, Alberto Bianco*

FULL ABSTRACT

Nature Reviews Electrical Engineering, 2024, in press

Clinical translation of graphene-based medical technology

Kostas Kostarelos, Carolina Aguilar, and Jose Garrido*

FULL ABSTRACT

Nature Nanotechnology 2024, in press [https://doi.org/10.1038/s41565-023-01570-5]

Nanoporous graphene-based thin-film microelectrodes for in vivo high-resolution neural recording and stimulation

Damià Viana^, Steven T. Walston^, Eduard Masvidal-Codina^, Xavier Illa, Bruno Rodríguez-Meana, Jaume del Valle, Andrew Hayward, Abbie Dodd, Thomas Loret, Elisabet Prats-Alfonso, Natàlia de la Oliva, Marie Palma, Elena del Corro, María del Pilar Bernicola, Elisa Rodríguez-Lucas, Thomas A. Gener, Jose Manuel de la Cruz, Miguel Torres-Miranda, Fikret Taygun Duvan, Nicola Ria, Justin Sperling, Sara Martí-Sánchez, Maria Chiara Spadaro, Clément Hébert, Sinead Savage, Jordi Arbiol, Anton Guimerà-Brunet, M. Victoria Puig, Blaise Yvert, Xavier Navarro, Kostas Kostarelos*, Jose A. Garrido*

FULL ABSTRACT

bioRxiv, 2024, doi.org/10.1101/2023.09.18.558196

Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets

Maria Stylianou, Thomas Kisby*, Despoina Despotopoulou, Helen Parker, Alexandra Thawley, Kiana Arashvand, Neus Lozano, Andrew MacDonald, Kostas Kostarelos*

FULL ABSTRACT

ACS Nano, 2023, 17 (24): 24919–24935

Pulmonary toxicity of boron nitride nanomaterials is aspect ratio dependent

Luis Visani^, Thomas Loret^, Yilin He, Morgan Legnani, Hazel Lin, Anne Marie Galibert, Alexander Fordham, Sonja Holme, Antonio Castillo, Francesco Bonaccorso, Alberto Bianco*, Emmanuel Flahaut*, Kostas Kostarelos*, Cyrill Bussy*

FULL ABSTRACT

Nanoscale, 2023, published online [https://doi.org/10.1039/D3NR04490D]

Delivery of graphene oxide nanosheets modulates glutamate release and normalizes amygdala synaptic plasticity to improve anxiety-related behavior

Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Neus Lozano, Kostas Kostarelos, Giada Cellot*, Laura Ballerini*

FULL ABSTRACT

Chemistry - A European Journal, 2023, e202301762

Graphene oxide nanosheets hamper glutamate mediated excitotoxicity and protect neuronal survival in an in vitro stroke model

Lorenza Tortella, Irene Santini, Neus Lozano, Kostas Kostarelos, Giada Cellot*, Laura Ballerini*

FULL ABSTRACT

bioRxiv, 2023, doi.org/10.1101/2023.08.22.553542

Engineering of a graphene oxide-based two-dimensional platform for immune activation and modulation

Despoina Despotopoulou, Maria Stylianou, Luis Miguel Arellano, Thomas Kisby, Neus Lozano, Kostas Kostarelos*

FULL ABSTRACT

Carbon nanotubes in macrophages: Imaging and chemical analysis by X-ray fluorescence microscopy

SHARE THIS

RECENT PUBLICATIONSVIEW ALL

In vivo biomolecule corona and the transformation of a foe into an ally for nanomedicine

First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses

Environmental and health impacts of graphene and other two-dimensional materials: a Graphene Flagship perspective

Clinical translation of graphene-based medical technology

Nanoporous graphene-based thin-film microelectrodes for in vivo high-resolution neural recording and stimulation

Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets

Pulmonary toxicity of boron nitride nanomaterials is aspect ratio dependent

Delivery of graphene oxide nanosheets modulates glutamate release and normalizes amygdala synaptic plasticity to improve anxiety-related behavior

Graphene oxide nanosheets hamper glutamate mediated excitotoxicity and protect neuronal survival in an in vitro stroke model

Engineering of a graphene oxide-based two-dimensional platform for immune activation and modulation

PART OF