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Creates advanced therapeutic and diagnostic tools by exploiting nanoscale materials in a safe and environmentally responsible manner

We are some of Tomorrow’s Labs

CORE MEMBERS

The NanoInflammation Lab studies how nanomaterials may cause inflammation or be used to modulate inflammation and control disease
The NanoCell Biology Lab unveils interactions of nanomaterials with living cells and their structural compartments
The NanoOmics Lab aims to harness the interactions of nanomaterials with biological matter for the discovery of novel biomarkers
The NanoTherapeutics Lab exploits the unique properties of nanoparticles to develop clinically translatable advanced medicines

AFFILIATE MEMBERS

Innovative neuroscience technologies, including wide bandwidth electrophysiology, multi-modal imaging and gene therapy
The Nanomedicine Lab designs, fabricates and characterizes advanced nanomaterials for biomedical and clinical use

RECENT PUBLICATIONSVIEW ALL

Nature Reviews Clinical Oncology 2025, 1-21

Targeting the glioblastoma resection margin with locoregional nanotechnologies

Kisby T, Borst GR, Coope DJ & Kostarelos K.

FULL ABSTRACT

Nature Communications 2025 16 (1), 3412

Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma

Xinming Liu, Hanan Abmanhal-Masarweh, Olivia Iwanowytsch, Emmanuel Okwelogu, Kiana Arashvand, Konstantina Karabatsou, Pietro I D'Urso, Federico Roncaroli, Kostas Kostarelos, Thomas Kisby*, Marilena Hadjidemetriou*

FULL ABSTRACT

bioRxiv, 2025.03. 29.646102

Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative spatiotemporal blood-brain barrier disruption

Lorena F. Fernandes, Chariya Peeyatu, Ben R. Dickie, Yu Siong Ho, Lydia A. Thompson, Noelia Hernandez, Neus Lozano, Kostas Kostarelos*, Thomas Kisby*

FULL ABSTRACT

Cell Reports Physical Science, 2025, 6, 1102342

Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets

Maria Stylianou, Thomas Kisby*, Despoina Despotopoulou, Helen Parker, Alexandra Thawley, Kiana Arashvand, Neus Lozano, Andrew S. MacDonald, Kostas Kostarelos*

FULL ABSTRACT

Small 2025, 21, 2404570

Safety Assessment of Graphene-Based Materials

Bengt Fadeel,* James Baker, Laura Ballerini, Cyrill Bussy, Fabio Candotto Carniel,Mauro Tretiach, Marco Pelin, Tina Buerki-Thurnherr, Tomi Kanerva, José Maria Navas,Ester Vázquez, Virginia Rodriguez Unamuno, Panja Lehtonen, Mar González,Hubert Rauscher, Juan Riego Sintes, Kostas Kostarelos, Alberto Bianco,*and Maurizio Prato*

FULL ABSTRACT

Nature Reviews Chemistry, 2025, Volume 9, 173–184

Biological and environmental degradation of two-dimensional materials

Sandra Vranic^, Rajendra Kurapati^, Kostas Kostarelos*, Alberto Bianco*

FULL ABSTRACT

Cell Reports Physical Science, 2024, in press

Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets

Maria Stylianou, Thomas Kisby*, Despoina Despotopoulou, Helen Parker, Alexandra Thawley, Kiana Arashvand, Neus Lozano, Andrew S. MacDonald, Kostas Kostarelos*

FULL ABSTRACT

Nature Reviews Materials, 2024, in press

In vivo biomolecule corona and the transformation of a foe into an ally for nanomedicine

Marilena Hadjidemetriou, Morteza Mahmoudi*, Kostas Kostarelos*

FULL ABSTRACT

Nature Nanotechnology, 2024, in press [https://doi.org/10.1038/s41565-023-01572-3]

First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses

Jack Andrews^, Shruti Joshi^, Evangelos Tzolos, Maaz Syed, Hayley Cuthbert, Livia Crica, Neus Lozano, Emmanuel Okwelogu, Jennifer Raftis, Lorraine Bruce, Craig Poland, Rodger Duffin, Paul Fokkens, John Boere, Daan Leseman, Ian Megson, Phil D. Whitfield, Kerstin Ziegler, Seshu Tammireddy, Marilena Hadjidemetriou, Cyrill Bussy, Flemming Cassee, David Newby, Kostas Kostarelos*, Mark Miller*

FULL ABSTRACT

ACS Nano, 2024, published online

Environmental and health impacts of graphene and other two-dimensional materials: a Graphene Flagship perspective

Hazel Lin, Tina Buerki-Thurnherr, Jasreen Kaur, Peter Wick, Marco Pelin, Aurelia Tubaro, Fabio Candotto Carniel, Mauro Tretiach, Emanuel Flahaut, Daniel Iglesias, Ester Vázquez, Giada Cellot, Laura Ballerini, Valentina Castagnola, Fabio Benfenati, Andrea Armirotti, Antoine Sallustrau, Mathilde Keck, Frédéric Taran, Cyrill Bussy, Sandra Vranic, Kostas Kostarelos, Mona Connolly, José Maria Navas, Florence Mouchet, Laury Gauthier, James Baker, Blanca Suarez-Merino, Tomi Kanerva, Maurizio Prato, Bengt Fadeel*, Alberto Bianco*

FULL ABSTRACT

RECENT NEWSVIEW ALL

16/03/2025

Centre Members Inspire at Brain Health Day

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29/11/2024

Dr Marilena Hadjidemetriou has been awarded a European Research Council (ERC) Starting Grant

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30/10/2024

CNTM hosts the University’s new President and Vice-Chancellor Prof Duncan Ivison

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17/10/2024

University partners with new national research hub which is revolutionising healthcare

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